MMSE scores below 22 would generally be interpreted as at least moderate impairment.Īnother drawback to the MoCA is that it takes longer than the MMSE to administer, such that it "might not fit into a standard office visit very well," the researchers noted. Ten of the 122 dementia patients in the study had MoCA scores above the researchers' suggested cutoff of 17, but MMSE scores less than 22. The MoCA may have been less useful than the MMSE in patients with overt dementia, Hochstetler and colleagues indicated. Overall, Hochstetler and colleagues characterized the MoCA as more challenging than the MMSE (hence the lower scores in each category). The MoCA also puts more weight on recall and attention-calculation performance, while de-emphasizing language skill.Īmong the three groups in the study, mean MMSE and MoCA scores were as follows: 001), whereas Language and Attention Index scores were lowest in the PPA. 001) but did not differ between DAT and PPA groups.However, in accordance with salient clinical features commonly observed in DAT versus PPA, Memory and Orientation Index scores were lowest in the DAT group (p <. Another use for which the MoCA may be better suited than the MMSE is in detecting the earliest stages of impairment. Results: The mean MoCA total score was significantly higher in controls compared to both patient groups (p <. The researchers said that, combined with a functional test, the MoCA could be helpful in classifying patients in the borderline area between mild impairment and dementia. "These data suggest that the MoCA, using a cutoff of ≥17, may be more useful than the MMSE to detect a range of mild cognitive impairment cases," Hochstetler and colleagues concluded in the poster. Those classifications would be considered more reliable than results from any single test, but may not be practical in many clinical and research settings. Here, we propose differential cut-off levels that can be used to identify mild and severe cognitive impairment with a simple and widely used first-level neurocognitive screening test: the Mini-Mental State Examination (MMSE). (Citing Lilly company policy, Hochstetler declined to speak on the record with MedPage Today.)Ī similar spread of MoCA scores, ranging from 17 to 30, was seen in 283 individuals identified as healthy controls in ADNI, which uses multiple tests to classify participants. Considering the need to intercept neurocognitive damage as soon as possible, it would be useful to extend cognitive test screening throughout the population. Among the 422 patients classified as mildly impaired, MMSE scores started at 21, whereas MoCA scores ranged from 13 to 30, according to a poster Hochstetler presented at the American Neurological Association annual meeting.
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